Corrected Calcium for Albumin Calculator (Payne Formula)
Endocrinology and clinical biochemistry audit. Approximately 40-45% of total serum calcium is bound to plasma proteins (primarily albumin). Hypoalbuminemia artificially lowers total calcium requiring adjustment.
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In-Depth Guide & Mathematical Methodology
🦴 Protein-Bound vs Free Ionized Calcium Physiology
Biological Significance: Only free ionized calcium (Ca2+) is physiologically active. Hypoalbuminemia causes pseudo-hypocalcemia.
Correction Rule: For every 1.0 g/dL drop in serum albumin below 4.0 g/dL, total serum calcium drops by 0.8 mg/dL.
Frequently Asked Questions (FAQ)
What is the Corrected Calcium for Albumin Calculator (Payne Formula) and how does it work?
Endocrinology and clinical biochemistry audit. Approximately 40-45% of total serum calcium is bound to plasma proteins (primarily albumin). Hypoalbuminemia artificially lowers total calcium requiring adjustment.
How do I use this Corrected Calcium for Albumin Calculator (Payne Formula)?
Enter Total Serum Calcium from lab report (mg/dL or mmol/L). Enter Serum Albumin from lab report (g/dL). View Albumin-Corrected Calcium and clinical calcemia status.
What mathematical formula is used in this calculation?
Payne Formula (1973): Corrected Calcium (mg/dL) = Measured Total Calcium + 0.8 × (4.0 - Albumin_g/dL). Normal Range: 8.5 to 10.5 mg/dL (2.12 - 2.62 mmol/L).
Is the Corrected Calcium for Albumin Calculator (Payne Formula) on FindCalculator free to use?
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